9/2/2023 0 Comments Typhim side effectsDrug resistance to many antibiotics has rapidly developed worldwide, making antibiotic therapy challenging. Treatment with antibiotics is recommended with empiric treatment until cultures are available. The initial treatment for severe illness is a third-generation cephalosporin, while milder illness may be treated with a fluoroquinolone antibiotic or azithromycin. Fewer organisms are required for infection from water than from food. Salmonella Typhi usually spreads through the ingestion of contaminated food or water. While 80% of these 5700 cases are in people who have traveled to regions with endemic Typhoid fever, many with the illness have not traveled at all. Outbreaks in the United States occur every year. Typhoid fever is most common in low and middle-income countries, with rates greater than 100 per 100,000 person-years in parts of Asia and Africa. Relapse of fever can occur in about 10% of untreated people. Typhoid fever results in a carrier state in 5% of people with high levels of excretion of Salmonella Typhi in the stool for over a year. Those who recover have a protracted illness over weeks to months. Cultures are obtainable from blood, stool, urine, bone marrow, duodenal contents, or skin rash. The diagnosis of Salmonella enterica serotype Typhi is confirmed by culture. Death can result in 12% to 30% of untreated illness. During the third week of illness, when there has been no treatment, enlargement of the liver and spleen may develop, along with ileocecal perforation, peritonitis, and septic shock in up to 30% of people. The second week of the disease is characterized by abdominal pain, constipation, and a faint macular rash on the trunk and abdomen. The fever increases as the bacteremia increases however, the heart rate may be lower than expected for the corresponding fever. Typhoid fever is a progressive "stepwise" fever in the first week of the illness. It then spreads by lymphatic and hematogenous routes. It penetrates the small bowel epithelium and enters the lymphoid tissue. The organism is ingested in contaminated food or water and survives the stomach acid. If you notice other side effects that you think are caused by this medicine, tell your doctor Call your doctor for medical advice about side effects.Typhoid fever predominantly results from Salmonella enterica serotype Typhi ( Salmonella Typhi), gram-negative bacteria that only cause disease in man. If you notice these less serious side effects, talk with your doctor:
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